Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer

MA Merritt; AC Green; CM Nagle; PM Webb; D Bowtell; G Chenevix-Trench; A Green; A DeFazio; D Gertig; N Traficante; S Moore; J Hung; S Fereday; K Harrap; T Sadkowsky; A Mellon; R Robertson; T Vanden Bergh; J Maidens; K Nattress; YE Chiew; A Stenlake; H Sullivan; B Alexander; P Ashover; S Brown; T Corrish; L Green; L Jackman; K Martin; B Ranieri; J White; V Jayde; L Bowes; P Mamers; T Schmidt; H Shirley; S Viduka; H Tran; S Bilic; L Glavinas; A Proietto; S Braye; G Otton; T Bonaventura; J Stewart; M Friedlander; D Bell; S Baron-Hay; A Ferrier; G Gard; D Nevell; B Young; C Camaris; R Crouch; L Edwards; N Hacker; D Marsden; G Robertson; P Beale; J Beith; J Carter; C Dalrymple; A Hamilton; R Houghton; P Russell; A Brand; R Jaworski; P Harnett; G Wain; A Crandon; M Cummings; K Horwood; A Obermair; D Wyld; J Nicklin; L Perrin; B Ward; M Davy; C Hall; T Dodd; T Healy; K Pittman; D Henderson; S Hyde; J Miller; J Pierdes; P Blomfield; D Challis; R McIntosh; A Parker; B Brown; R Rome; D Allen; P Grant; R Laurie; M Robbie; D Healy; T Jobling; T Maniolitas

Journal article

Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer

MA Merritt, AC Green, CM Nagle, PM Webb, D Bowtell, G Chenevix-Trench, A Green, A DeFazio, D Gertig, N Traficante, S Moore, J Hung, S Fereday, K Harrap, T Sadkowsky, A Mellon, R Robertson, T Vanden Bergh, J Maidens, K Nattress Show all

International Journal of Cancer | Published : 2008

DOI: 10.1002/ijc.23017

Abstract

Chronic inflammation has been proposed as the possible causal mechanism that explains the observed association between certain risk factors, such as the use of talcum powder (talc) in the pelvic region and epithelial ovarian cancer. To address this issue we evaluated the potential role of chronic local ovarian inflammation in the development of the major subtypes of epithelial ovarian cancer. Factors potentially linked to ovarian inflammation were examined in an Australia-wide case-control study comprising 1,576 women with invasive and low malignant potential (LMP) ovarian tumours and 1,509 population-based controls. We confirmed a statistically significant increase in ovarian cancer risk as..

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